Table 2.

Correlations between the LGR5 transcripts mRNA levels and the mRNA levels of different biomarkers

		LGR5FL/RPII	LGR5Δ5/RPII	LGR5Δ8/RPII	LGR5all/RPII
EMTmarkers
TWIST1	rs	0.379	0.258	0.177	0.350
	p-value	0.001*	0.031	0.143	0.003
	n	70	70	70	70
SNAI1	rs	0.320	0.330	0.228	0.158
	p-value	0.007	0.005	0.057	0.191
	n	70	70	70	70
ZEB2	rs	0.450	0.456	0.270	0.312
	p-value	< 0.0001*	< 0.0001*	0.018	0.006
	n	76	76	76	76
MMP7	rs	0.373	0.288	0.308	0.363
	p-value	0.001*	0.016	0.01	0.002*
	n	70	70	70	70
TCF7	rs	0.581	0.490	0.337	0.553
	p-value	< 0.0001*	< 0.0001*	0.004	< 0.0001*
	n	70	70	70	70
Vimentin	rs	0.594	0.624	0.454	0.402
	p-value	< 0.0001*	< 0.0001*	< 0.0001*	0.001*
	n	70	70	70	70
TGFβ	rs	0.402	0.305	0.285	0.261
	p-value	< 0.0001*	0.007	0.013	0,023
	n	76	76	76	76
Stem cell markers
NANOG	rs	0.187	0.137	0.219	0.383
	p-value	0.121	0.259	0.068	0.001*
	n	70	70	70	70
Oct3/4	rs	0.251	0.216	0.377	0.207
	p-value	0.036	0.073	0.001*	0.086
	n	70	70	70	70
Proteins involved in the metastatic process
P4HA1	rs	0.390	0.236	0.276	0.167
	p-value	< 0.0001*	0.037	0.014	0.144
	n	78	78	78	78
CTGF	rs	0.492	0.469	0.302	0.301
	p-value	< 0.0001*	< 0.0001*	0.012	0.013
	n	68	68	68	68
IGF2	rs	0.498	0.485	0.316	0.271
	p-value	< 0.0001*	< 0.0001*	0.009	0.025
	n	68	68	68	68
OPN	rs	0.281	0.240	0.301	0.079
	p-value	0.020	0.049	0.013	0.522
	n	68	68	68	68
Wnt signaling modulating genes
RNF43	rs	−0.129	−0.171	−0.204	−0.123
	p-value	0.287	0.158	0.090	0.311
	n	70	70	70	70
RSPO1	rs	0.097	0.131	0.040	0.051
	p-value	0.427	0.284	0.743	0.678
	n	69	69	69	69

Bivariable Spearman’s Rho test. r_s: correlation coefficient. The underlined genes have been shown to be Wnt- target genes. P-values were adjusted by the Bonferroni correction.* p-value ≤0.003 indicates statistical significance