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. 2019 Feb 15;13:10. doi: 10.1186/s40246-019-0192-8

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — P0-3.9GFPCre E8.5 embryos exhibit extensive CRE-mediated recombination prior to lens placode formation. At E8.5, X-Gal staining in Le-Cre embryos (top) remained restricted to the developing pancreas. In contrast, P0-3.9GFPCre embryos (bottom) exhibited many patches of X-Gal stained tissue throughout the embryo, with particularly high numbers of blue clones in the developing heart region