Fig. 2.

Co-occurrence of MYC amplification and TP53 mutations is associated with age at first pregnancy. a Timeline of 153 patients with available data on age at first pregnancy. Each line represents an individual patient from age at first pregnancy (start of the line) to age at breast cancer diagnosis (end of the line). Late parous patients (upper) (n = 71) and early parous patients (bottom) (n = 82) are grouped according to median age at first pregnancy (25 years). Gray diamond represents the median age at first pregnancy and at diagnosis in the two groups. Lines are colored according to TP53 mutations (green) MYC amplification (dark red) and the co-occurrence of both (red). b Comparison of MYC expression in early (n = 51) and late parous patients (n = 45). Each dot represents an individual patient and is colored according to TP53 mutations (green) MYC amplification (dark red) and the co-occurrence of both (red). P value is derived from the multivariate linear regression analysis adjusted for potential confounders. c MYC expression according to TP53 mutations, MYC amplification or the co-occurrence of both. P value is derived from the Kruskal–Wallis test