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RNF20 and H2Bub1 depletion escalates oncogenic behavior in late-stage HGSOC and SKOV3 cells. Cell lines which retained H2Bub1 were selected and RNF20 was silenced by pooled siRNAs. (A) Western blot was used to validate RNF20 knockdown and the resulting H2Bub1 downregulation. (B) RNF20/H2Bub1 downregulation promoted trans-well migration in HGSOC cell lines Kuramochi, OVKATE and SKOV3. *, p ≤ 0.05; ****, p ≤ 0.0001.
