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Pep8 inhibits tumor cell growth in Rbm38- and p53-dependent manners. A Pen-Pep8 (5 μM) treatment decreases colony formation in wild-type, but not Rbm38- or p53-null RKO cells. B Pen-Pep8 (5 μM) treatment reduces MCF7 tumor sphere formation in wild-type, but not in Rbm38- or p53-null MCF7 cells. Tumor spheres (> 50 μm) counted 1 week after peptide treatment. C Quantification of tumor spheres from B. Values represent the mean ± SEM of three independent experiments (* p=0.0013).
