Table 3:
Performance of KDIGO thresholds for absolute SCr rise, percent SCr rise and combination to predict mortality using KIDGO
| Absolute SCr Rise | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Threshold | nAKI Incidence | Mortality | Sensitivity | Specificity | p-value** | NPV | PPV | LR + | LR− | AUC | p-value* | |
| ≤29 weeks | ≥0.3 mg/dl | 95/170 (55.9%) | 22 (23.2%) | 0.92 | 0.5 | ref | 0.97 | 0.23 | 1.8 | 0.16 | 0.71 | ref |
| 29–36 weeks | ≥0.3 mg/dl | 47/467 (10.1%) | 7 (14.9%) | 0.54 | 0.91 | ref | 0.98 | 0.15 | 7.7 | 0.51 | 0.73 | ref |
| ≥36 weeks | ≥0.3 mg/dl | 49/353 (13.9%) | 5 (10.2%) | 0.42 | 0.87 | ref | 0.98 | 0.1 | 4.7 | 0.67 | 0.64 | ref |
| Percent SCr Rise | ||||||||||||
| Threshold | nAKI Incidence | Mortality | Sensitivity | Specificity | p-value* | NPV | PPV | LR+ | LR− | AUC | p-value* | |
| ≤29 weeks | ≥ 50% | 89/170 (52.4%) | 17 (19.1%) | 0.70 | 0.51 | 1.00 | 0.91 | 0.19 | 1.6 | 0.59 | 0.61 | 0.02 |
| 29–36 Weeks | ≥ 50% | 67/467 (14.4%) | 6 (8.9%) | 0.46 | 0.87 | 0.001 | 0.98 | 0.09 | 5.4 | 0.62 | 0.66 | 0.37 |
| ≤29 weeks | ≥ 50% | 72/353 (20.4%) | 5 (6.9%) | 0.42 | 0.80 | <0.0001 | 0.98 | 0.07 | 1.7 | 0.73 | 0.61 | 0.7 |
| Absolute and/ or Percent SCr Rise | ||||||||||||
| Threshold | nAKI Incidence | Mortality | Sensitivity | Specificity | p-value* | NPV | PPV | LR+ | LR− | AUC | p-value* | |
| ≤29 weeks | ≥ 0.3/ 50% | 100/ 170 (58.8%) | 22 (22.0%) | 0.92 | 0.47 | 0.06 | 0.97 | 0.22 | 1.7 | 0.17 | 0.69 | 0.02 |
| 29–36 Weeks | ≥ 0.3/ 50% | 78/467 (16.7%) | 8 (10.3%) | 0.61 | 0.85 | <0.0001 | 0.99 | 0.1 | 4.1 | 0.46 | 0.73 | 0.89 |
| ≥36 weeks | ≥ 0.3/ 50% | 76 / 353 (21.5%) | 7 (9.2%) | 0.58 | 0.80 | <0.0001 | 0.98 | 0.09 | 2.9 | 0.53 | 0.69 | 0.41 |
*
p-value for AUC - reference is absolute SCr change
**
p-value for specificity - reference is absolute SCr change