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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Cancer Res. 2018 Nov 12;79(4):706–719. doi: 10.1158/0008-5472.CAN-18-1207

Figure 3.

Figure 3.

Muscle AT1 expression is elevated in humans and mice with cancer cachexia. (A) AT1 and (C) MasR mRNA expression in rectus abdominus muscle tissue from cachectic (>5% weight loss) patients with pancreatic ductal adenocarcinoma (PDAC) cancer compared with non-cancer controls (unpaired t test; *P<0.05; Control, n=9; PDAC, n=12). (B) AT1 and (D) MasR mRNA expression was not related to age (linear regression analysis; n=21). Representative western blot of (E) AT1 and (F) MasR protein expression and corresponding quantification in gastrocnemius muscles from PBS and C-26 tumor-bearing mice (unpaired t test; **P<0.01; n=7).