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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Eur J Pharm Biopharm. 2019 Jan 8;136:18–28. doi: 10.1016/j.ejpb.2019.01.006

Figure 4.

Figure 4.

a. Cellular association assay of MDM 1:10 complexed with 0 nM, 100 nM and 500 nM siMDR-1 in A2780-ADR and MCF7-ADR. MDM Rh-PE are MDMs containing 1% mole of Rh-PE. Results indicate mean ± SD, n=3. ****p ≤ 0.0001. b. Analysis of the co-localization of DOX and FAM-siRNA in MCF7 ADR cell line treated with Lipofectamine FAM-siRNA, MDM 1:10 loaded with DOX and MDM 1:10 co-loaded with DOX and FAM-siRNA using flow cytometry. FL1-H indicates the fluorescence signal at 530 nm. FL2-H indicate the fluorescence signal at 585 nm.