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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Eur J Pharm Biopharm. 2019 Jan 8;136:18–28. doi: 10.1016/j.ejpb.2019.01.006

Figure 7.

Figure 7.

Cytotoxicity assay of MDM 1:10 formulations loaded with DOX or DOX/siRNA against a, MCF7 ADR cells and b, A2780 ADR cells. Abscissa labelled “3.67/500/1.7” indicates 3.67 μM nano-preparation loaded with 500 nM siRNA and 1.7 μM DOX. c, Cytotoxicity assay of MCF7 sensitive cell line and MCF7 ADR cell line treated with free DOX 3.4 μM, free DOX 3.4 μM with 200 nM of siMDR-1, MDM 1:10 loaded with 3.4 μM DOX and MDM 1:10 loaded with 3.4 μM DOX and 200 nM siMDR-1. d, Cytotoxicity assay of A2780 ADR cells treated with MDM 1:10 or MDM 1:10 siMDR-1 together with free DOX HCl 3.4 μM. Abscissa labelled “3.68/200” indicates 3.68 μM nano-preparation loaded with 200 nM siRNA. All results indicate mean ± SD, n=3. **P<0.01, ***P<0.001****P<0.0001.