Table 2.

Estimates for PiB-PET variables and APOEε4 carrier status predicting HADS-anxiety subscale scores in serial multivariate models

Predictor	Unstandardized β-estimate (SE)	95% CI	Model R2	P-value
Series 1 (n = 118): neocortical PiB+/PiB− groups and APOEε4 carrier status
PiB+ group (reference PiB−)	+ 0.2 (0.5)	− 0.9 to 1.3	0.16	0.73
APOEε4 carrier (reference non-carrier)	+ 0.4 (0.6)	− 0.7 to 1.5	0.16	0.47
PiB+ group * APOEε4 carrier	+ 2.3 (1.3)	− 0.3 to 4.9	0.19	0.07
Series 2 (n = 118): PiB stages (reference PiB stage 0) and APOEε4 carrier status
PiB Stage 1	− 0.5 (0.6)	− 1.7 to 0.8	0.19	0.46
PiB Stage 2	+ 1.8 (0.9)	0.1 to 3.6		0.04
PiB Stage 1 * APOEε4 carrier	+ 1.2 (1.4)	− 1.5 to 3.9	0.24	0.38
PiB Stage 2 * APOEε4 carrier	+ 4.3 (1.7)	1.0 to 7.6		0.01
Series 3 (n = 43): continuous PiB measures in neocortical PiB+ participants
Neocortical PiB	+ 0.6 (1.0)	− 1.4 to 2.6	0.20	0.54
Striatal PiB	+ 3.0 (1.6)	− 0.1 to 6.1	0.26	0.07
Thalamus PiB	+ 6.7 (2.5)	1.7 to 11.7	0.32	0.01
Amygdala PiB	+ 9.5 (4.0)	1.6 to 17.3	0.29	0.02

Each row shows results for the predictor or predictors of interest in separate models. All models are adjusted for age, sex, education, MMSE, and GDS scores. PiB Stage 0 (low neocortical, low striatal PiB). PiB Stage 1 (high neocortical, low striatal PiB). PiB Stage 2 (high neocortical, high striatal PiB). CI confidence interval, GDS Geriatric Depression Scale, HADS-anxiety Hospital Anxiety and Depression Scale, MMSE Mini-Mental State Examination, PiB Pittsburgh Compound B