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. Author manuscript; available in PMC: 2019 Feb 17.
Published in final edited form as: Int J Cancer. 2018 Apr 16;143(5):1259–1268. doi: 10.1002/ijc.31401

Table 1.

Differential effect of CEE and E2 in three breast cancer models

MCF-7 xenografts
 NMU model
 ACI model
Parameters E2 CEE E2 CEE E2 CEE
Uterine weight ↑↑↑ ↑↑↑ ↑↑↑ ↑↑↑ N/A N/A
Tumor incidence N/A N/A ↑↑↑ ↔ ↑↑↑ ↔ or ↑
# of tumor per animal N/A N/A ↑↑↑ ↔ ↑↑↑ ±
Tumor growth ↑↑↑ ↔ N/A N/A N/A N/A
Proliferation (Ki67) ↑↑↑ ↔ Variable Variable ↑↑↑ ↓↓↓
Apoptosis ↓↓↓ ↑↑↑ Variable Variable ↓↓↓ ↑↑↑

±: equivocal effect.

↔: no effect.