Table 2.
Results of antifungal activity (expressed as MIC in μg mL−1), cytotoxic activity (expressed as CC50 in μg mL−1), and selectivity index for extract and fractions of I. laurina leaves.
| MIC (μg mL−1) | |||||
|
| |||||
| Microorganisms | EE | HF | CF | EAF | BF |
|
| |||||
| C. albicans ATCC 28366 | 46.8 | 1,500 | >3,000 | 93.8 | 11.7 |
| C. glabrata ATCC 15126 | 11.7 | 187.5 | >3,000 | 11.7 | 23.4 |
| C. tropicalis ATCC 13803 | 93.8 | 3,000 | >3,000 | 93.8 | 46.8 |
|
| |||||
| CC 50 (μg mL−1) | |||||
|
| |||||
| Vero cells | 352 ± 5 | 384 ± 9 | >512 | >512 | >512 |
|
| |||||
| SI | |||||
|
| |||||
| Microorganisms | EE | HF | CF | EAF | BF |
|
| |||||
| C. albicans ATCC 28366 | 0.9 | - 0.6 | > - 0.8 | > 0.7 | > 1.6 |
| C. glabrata ATCC 15126 | 1.5 | 0.3 | > - 0.8 | > 1.6 | > 1.3 |
| C. tropicalis ATCC 13803 | 0.6 | - 0.9 | > - 0.8 | > 0.7 | > 1.0 |
EE = ethanol extract; HF = hexane fraction; CP = chloroform fraction; EAF = ethyl acetate fraction; BF = n-butanol fraction. SI: selectivity index. ATCC: American Type Culture Collection.