Table 5.
Comparison of differences in observation indicators after 4 and 8 weeks treatment in the 3 groups.
| Indicators | Control group (n = 52) | Allopurinol group (n = 55) | Chuanhutongfeng mixture group (n = 58) | |||
|---|---|---|---|---|---|---|
| 4 weeks | 8 weeks | 4 weeks | 8 weeks | 4 weeks | 8 weeks | |
| ∆ESR (mm/h) | -8.00 ± 3.80 | -9.00 ± 3.60 | -16.20 ± 9.30a | -17.30 ± 9.20 | -16.40 ± 4.30a | -19.00 ± 4.60b |
| ∆CRP (mg/L) | -1.20 ± 0. 50 | -2.50 ± 0.50 | -11.80 ± 7.80a | -12.00 ±7.70b | -15.40 ± 8.90ac | -15.50 ± 8.90bd |
| ∆Pain score | -1.44 ± 0.51 | -1.55 ± 0.50 | -2.32 ± 0.60a | -2.41 ± 0.53b | -2.36 ± 0.53a | -2.56 ± 0.46b |
| ∆Swelling score | -1.11 ± 0.42 | -1.15 ± 0.42 | -1.46 ± 0.51a | -1.47 ± 0.41b | -1.47 ± 0.47a | -1.51 ± 0.47b |
| ∆Restricted movement score | -1.00 ± 0.49 | -1.03 ± 0.49 | -1.47 ± 0.48a | -1.48 ± 0.48b | -1.49 ± 0.50a | -1.53 ± 0.46b |
| ∆SUA (μmol/L) | -14.00 ± 12.00 | -26.00 ± 23.00 | -64.00 ± 21.00a | -70.00 ± 21.00b | -90.00 ± 47.00a | -170.00 ± 49.00bd |
| ∆eGFR (ml/min/1.73 m2) | 0.40 ± 2.10 | 0.40 ± 2.90 | -3.00 ± 2.70a | -3.90 ± 3.60b | 3.20 ± 1.70ac | 5.70 ± 2.60bd |
| ∆FPG (mmol/L) | -0.05± 0.22 | -0.10 ± 0.22 | -0.10 ± 0.25 | -0.10 ± 0.25 | -0.22 ± 0.32 | -0.20 ± 0.32 |
| ∆TG (mmol/L) | -0.56 ± 0.37 | -0.58 ± 0.37 | -0.63 ± 0.36 | -0.68 ± 0.35 | -0.61 ± 0.31 | -0.65 ± 0.31 |
| ∆TC (mmol/L) | -0.22 ± 0.23 | -0.18 ± 0.23 | -0.31 ± 0.22 | -0.36 ± 0.22 | -0.43 ± 0.19 | -0.49± 0.19 |
| ∆CCL2 (pg/mL) | -21.00 ± 24.00 | -32.00 ± 24.00 | -88.00 ± 76.00a | -163.00 ± 136.00b | -97.00 ± 89.00a | -174.00 ± 129.00bd |
| ∆CXCL8 (pg/mL) | -14.00 ± 18.00 | -21.00 ± 18.00 | -22.00 ± 28.00a | -43.00 ± 38.00b | -93.00 ± 93.00ac | -212.00 ± 133.00bd |
| ∆miR-486-5p | 0.12 ± 0.12 | 0.15 ± 0.16 | 0.58 ± 0.53a | 3.28 ± 0.55b | 0.78 ± 0.67a | 5.78 ± 1.72bd |
| ∆miR-339-5p | 0.08 ± 0.16 | 0.11 ± 0.19 | 0.09 ± 0.14 | 1.69 ± 0.47b | 0.60 ± 0.49ac | 4.25 ± 1.61bd |
| ∆miR-361-5p | 0.13 ± 0.10 | 0.28± 0.15 | 0.25 ± 0.15 | 4.43 ± 1.06b | 0.63 ± 0.20a | 6.53 ± 2.79bd |
Note. ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; eGFR: estimate glomerular filtration rate; FBG: fasting blood-glucose; TG: triglyceride; TC: total cholesterol; SUA: serum uric acid; CCL2: chemokine (C-C motif) ligand 2; CXCL8: chemokine (C-X-C motif) ligand 8. ∆ values: the value of index which were measured before or after treatment subtracted their baseline value; compared with the control group after 4 weeks aP < 0.05, 8 weeks, bP < 0.05; compared with the allopurinol group after 4 weeks, cP< 0.05, 8 weeks, dP< 0.05.