Table 1.
Demographic, clinical, and pathological characteristics of participants (N=356)
| Characteristics | Mean (SD) or N (%) |
|---|---|
| Clinical | |
| Age at death, years | 90.5 (6.16) |
| Age 90+ | 202 (56.7%) |
| Sex, men | 99 (27.8%) |
| Education, years | 14.6 (3.09) |
| Last MMSE score proximate to death | 20.5 (9.33) |
| Last clinical evaluation, years | 1.1 (1.41) |
| Cognition, proximate-to-death | |
| Global | −0.9 (1.15) |
| Episodic Memory | −0.9 (1.27) |
| Semantic Memory | −0.8 (1.34) |
| Working Memory | −0.8 (1.14) |
| Perceptual Speed | −1.05 (1.02) |
| Perceptual Orientation | −0.5 (1.10) |
| Neuropathologic | |
| PMI, hours | 8.4 (5.67) |
| AD pathology score | 0.8 (0.62) |
| Macroinfarcts presence | 125 (35.1%) |
| Cortical, n | 56 |
| Subcortical, n | 97 |
| Brainstem/cerebellum, n | 23 |
| Microinfarcts | 133 (37.4%) |
| Cortical WS | 50 (14.0%) |
| Location | |
| Midfrontal anterior WS, n | 18 |
| White matter anterior WS, n | 15 |
| Posterior WS, n | 24 |
| Quantity | |
| Single, n | 33 |
| Multiple, n | 17 |
| Other brain regions | 105 (29.5%) |
| Quantity | |
| Single, n | 71 |
| Multiple, n | 34 |
Abbreviations: PMI – post-mortem interval; WS – watershed; MMSE – Mini-Mental-State-Examination