Figure 1.

A DNA nanorobot for target therapy. A, Construction of nanorobot‐Th by DNA origami. The robot opened itself upon sensing nucleolin. B, The action mechanism of nanorobot‐Th in plasma with HUVECs. C, Specific targeting of the nanorobot (green) to the blood vessel‐rich regions (brown). FITC‐labelled nanorobots were injected intravenously into mice‐bearing MDA‐MB231 tumours. Tumours were harvested 8 h later, and tumour sections were stained with an anti‐CD34 antibody and examined by confocal microscopy. D, The therapeutic mechanism of nanorobot‐Th within tumour vessels. E, Representative pictures of the tumours from the MDA‐MB231 tumour‐bearing mice after treatment with saline and nanorobot‐Th. Adapted with permission from Reference Li et al.3 Copyright 2018 Nature Publishing Group