Table 3.
GO function and KEGG pathway enrichment analysis of DEGs
| ID | Terms | Count | P value | Genes |
|---|---|---|---|---|
| Biological process | ||||
| GO:0001666 | Response to hypoxia | 10 | 1.12E‐07 | KCNMA1, EGR1, CCL2, EPAS1, SMAD4, THBS1, ENG, SRF, PLAU, MB |
| GO:0007179 | Transforming growth factor β receptor signalling pathway | 6 | 7.24E‐05 | CCL2, ID1, SMAD4, PARP1, GDF15, ENG |
| GO:0007165 | Signal transduction | 15 | 9.48E‐04 | SH3GL3, EPAS1, CRABP2, TANK, PLAUR, CXCL10, THBD, CD274, IL1B, INPP4B, … |
| GO:0006935 | Chemotaxis | 4 | 2.62E‐03 | ACKR3, PLAU, CXCL10, PLAUR |
| GO:0071407 | Cellular response to organic cyclic compound | 4 | 2.70E‐03 | CCL2, IL1B, STAT1, ARHGDIA |
| Cellular components | ||||
| GO:0070062 | Extracellular exosome | 33 | 1.31E‐07 | GALNT3, GNAI3, SLPI, PLAU, CDH1, CLDN11, EPCAM, TOR1A, IL1B, MB, … |
| GO:0005615 | Extracellular space | 21 | 1.23E‐06 | ADNP, CXCL10, FBLN1, THBD, CST6, HIST2H2BE, TACSTD2, SERPINB5, SLPI, IL1B, … |
| GO:0009986 | Cell surface | 9 | 1.41E‐04 | EPCAM, THBD, SLC1A3, ACKR3, AREG, THBS1, ALPP, FGFBP1, ENG |
| GO:0016328 | Lateral plasma membrane | 4 | 1.69E‐03 | EPCAM, TACSTD2, CDH1, GJB2 |
| GO:0048471 | Perinuclear region of cytoplasm | 9 | 1.72E‐03 | GALNT3,VAMP8, CDH1, MAP7, NDRG1, ACKR3, LAMC2, PRKACB, STAT1 |
| Molecular functions | ||||
| GO:0005515 | Protein binding | 57 | 4.87E‐04 | FOSL2, ATP6AP2, TNNC1, CRABP2, SDC2, CXCL10, EPCAM, SPRED2, SERPINA1, PRKACB, … |
| GO:0008201 | Heparin binding | 5 | 6.73E‐03 | CCL2, LAMC2, THBS1, FGFBP1, CXCL10 |
| GO:0008134 | Transcription factor binding | 6 | 1.07E‐02 | EPAS1, ID1, PBX1, ID3, PARP1, SRF |
| GO:0047718 | Indanol dehydrogenase activity | 2 | 1.40E‐02 | AKR1C3, AKR1C1 |
| GO:0070051 | Fibrinogen binding | 2 | 1.40E‐02 | FBLN1, THBS1 |
| KEGG pathyways | ||||
| hsa04350 | TGF‐β signalling pathway | 5 | 1.91E‐03 | ID2, ID1, SMAD4, ID3, THBS1 |
| hsa04610 | Complement and coagulation cascades | 4 | 9.42E‐03 | THBD, SERPINA1, PLAU, PLAUR |
| hsa04390 | Hippo signalling pathway | 5 | 1.51E‐02 | ID2, ID1, SMAD4, CDH1, AREG |
| hsa04062 | Chemokine signalling pathway | 5 | 2.99E‐02 | GNAI3, CCL2, PRKACB, STAT1, CXCL10 |
| hsa05200 | Pathways in cancer | 7 | 3.68E‐02 | GNAI3, EPAS1, SMAD4, CDH1, LAMC2, PRKACB, STAT1 |
DEG, differentially expressed genes; GO, Gene Ontology enrichment analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes.