Figure 3.
Action potential parameters of spontaneously firing DMD and control iPSC‐CMs. (A‐H) Action potential parameters of iPSC‐CMs. (A) Beat rate; (B) Maximal diastolic potential (MDP); (C) Action potential peak; (D) Action potential amplitude; (E) Maximal rate of Phase 0 depolarization (dV/dtmax); (F‐H) Action potential duration at 20/50/90% of repolarization (APD20/50/90). (I) Representative action potentials displaying prolonged APDs in DMD iPSC‐CMs compared to control iPSC‐CMs. Control n = 25; DMD female, n = 21; DMD male, n = 23. One‐way ANOVA followed by Holm‐Sidak post‐hoc analysis. *P < 0.05, **P < 0.01, ***P < 0.001