Figure 1.

Effect of rapamycin treatment on mouse growth and long bone length. WT and OI male mice were treated with dietary rapamycin (Rapa) or control diet for 5 weeks from 3 weeks to 8 weeks of age. N = 8 mice per genotype and treatment. (A) Mouse body weight (g) at start of treatment and at end of 5 weeks treatment (+Rapa). Mean with 95% CI. (B) Tibial length at end of the treatment. Control and rapamycin (Rapa) treatment groups are indicated, ● WT, ■ OI. All values are the mean ± SD; Two‐way ANOVA with Tukey's post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001. All WT and OI body weight data were significantly different (P < 0.0001) between 3 week and 8 week samples. For clarity in the figure, significance bars are not in shown between these samples