Table 1.
Characteristics of six genetic variants with vitamin D levels
| SNP | Position | Nearby genes | EA/NEA | EAF | Beta | SE | P value |
|---|---|---|---|---|---|---|---|
| rs3755967 | 4:72828262 | GC | C/T | 0.72 | 0.089 | 0.0023 | 4.74E‐343 |
| rs12785878 | 11:70845097 | NADSYN1/DHCR7 | T/G | 0.75 | 0.036 | 0.0022 | 3.80E‐62 |
| rs10741657 | 11:14871454 | CYP2R1 | A/G | 0.40 | 0.031 | 0.0022 | 2.05E‐46 |
| rs17216707 | 20:52165769 | CYP24A1 | T/C | 0.79 | 0.026 | 0.0027 | 8.14E‐23 |
| rs10745742 | 12:94882660 | AMDHD1 | T/C | 0.40 | 0.017 | 0.0022 | 1.88E‐14 |
| rs8018720 | 14:38625936 | SEC23A | G/C | 0.18 | 0.017 | 0.0029 | 4.72E‐09 |
EA, Effect Allele; EAF, Effect Allele Frequency; NEA, Non‐Effect Allele; SE, standard error; SNP, single‐nucleotide polymorphism. Beta is the regression coefficient based on the vitamin D raising allele (effect allele). Beta > 0 and Beta < 0 means that this effect allele regulates increased and reduced vitamin D levels or bone mineral density, respectively.