Table 2.
The diagnostic efficiency of models in differentiating SCLC patients and the controls
| SCLC vs control | AUC (95% Cl) | SN (%) | SP (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|
| PTNa | 0.887 (0.806‐0.948) | 70.3 | 94.4 | 90.9 | 81.8 |
| ProGRP | 0.784 (0.694‐0.874) | 60.2 | 82.2 | 70.6 | 74.4 |
| NSE | 0.763 (0.669‐0.857) | 49.2 | 86.7 | 72.4 | 70.6 |
| PTN + ProGRP + NSE | 0.914 (0.857‐0.971) | 80.5 | 98.9 | 98.1 | 87.7 |
AUC, areas under the curves; NPV, nagative predictive value; NSE, neuron‐specific enolase; PPV, positive predictive value; ProGRP, progastrin‐releasing peptide; PTN, pleiotrophin; SN, sensitivity; SP, specificity; SCLC, serum of patients with small cell lung cancer.
a
The diagnostic cut‐off value was 258.18 ng/mL.