Figure 1.

Ursolic acid preserves cardiac function in mice treated with doxorubicin in both early and late injury phases. A, Heart echocardiography. Upper panel, Doxorubicin + Ursolic acid group (UA + DOX); lower panel, Doxorubicin group (DOX). LVIDd, left ventricle internal diameter in diastole; LVIDs, left ventricle internal diameter in systole. B, Ursolic acid treatment significantly improved FS at both 7 and 28 days, compared with the Doxorubicin control group (n = 5, *P < 0.05). C, Ursolic acid significantly improved EF at both 7 and 28 days, compared with the doxorubicin control (n = 5, *P < 0.05)