Figure 2.

Ursolic acid increases NO production, inhibits ROS generation and decreases CKMB releasing in the mouse heart after doxorubicin treatment. Mice were divided into three groups: Sham group, Doxorubicin group and Doxorubicin + Ursolic acid group. A, DOX significantly decreased NO production compared with the sham (n = 5, **P < 0.05), while ursolic acid significantly increased NO production compared with the doxorubicin control (n = 5, *P < 0.01). B, Ursolic acid significantly inhibited ROS production compared with doxorubicin (n = 5, *P < 0.05). C, Ursolic acid significantly decreased CKMB releasing from the hearts in mice compared with doxorubicin (n = 5, *P < 0.05)