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. 2019 Jan 4;23(3):2174–2183. doi: 10.1111/jcmm.14130

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© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ursolic acid inhibits inflammation and fibrosis in the mouse heart after doxorubicin treatment. A, H&E staining of heart. a, Sham group; b, Doxorubicin + Ursolic acid group; c, Doxorubicin group. Ursolic acid overtly decreased inflammatory cell infiltration compared with doxorubicin (Bar = 50 μm; arrows indicate inflammatory cells). B, Masson's staining of heart samples. a, Sham group; b, Doxorubicin + Ursolic acid group; c, Doxorubicin group (Bar = 20 μm). Ursolic acid significantly decreased fibrosis compared with the doxorubicin control (n = 5, *P < 0.01)