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. 2019 Jan 4;23(3):2174–2183. doi: 10.1111/jcmm.14130

Figure 5.

Figure 5

Effects of ursolic acid on phosphorylation levels of AKT and eNOS. Protein levels were detected by immunoblot. A, Effects of ursolic acid on AKT and p‐AKT. Lanes 1 to 3 represent the Sham, Doxorubicin and Doxorubicin + Ursolic acid treatment groups respectively. B, doxorubicin significantly decreased AKT phosphorylation compared with sham (n = 5, **P < 0.05), while ursolic acid significantly increased AKT phosphorylation compared with doxorubicin (n = 5, *P < 0.05). C, Effect of ursolic acid on p‐eNOS. Lanes 1 to 3 represent the Sham, Doxorubicin and Doxorubicin + Ursolic acid treatment groups respectively. D, doxorubicin significantly decreased eNOS phosphorylation compared with sham (n = 5, **P < 0.01), while ursolic acid significantly increased eNOS phosphorylation compared with doxorubicin (n = 5, *P < 0.01)