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. 2019 Jan 4;23(3):2174–2183. doi: 10.1111/jcmm.14130

Figure 6.

Figure 6

Effects of ursolic acid on eNOS and NOX4. A, Effect of ursolic acid on eNOS. Lanes 1 to 3 represent the Sham, Doxorubicin and Doxorubicin+Ursolic acid treatment groups respectively. B, doxorubicin significantly increased eNOS expression compared with sham (n = 5, **P < 0.05), while ursolic acid significantly increased eNOS expression compared with doxorubicin (n = 5, *P < 0.01). C, doxorubicin significantly increased NOX4 expression compared with sham (n = 5, *P < 0.01), while ursolic acid significantly decreased Nox4 expression compared with doxorubicin (n = 5, *P < 0.01). D, Effect of ursolic acid on the expression of eNOS monomer and dimer. Lanes 1 to 3 represent the Sham, Doxorubicin and Doxorubicin + Ursolic acid treatment groups respectively. E. doxorubicin significantly increased eNOS monomer/dimer ratio compared with sham (n = 3, *P < 0.05), while ursolic acid significantly decreased eNOS monomer/dimer ratio compared with doxorubicin (n = 3, *P < 0.05)