Figure 6.

The detection of Tn antigen‐H‐Ras‐EMT signalling in CRC patients. A and B, The bioinformatics analysis using transcriptome data of 438 CRC patients in TCGA cohort revealed that Cosmc expression was negatively correlated with H‐Ras expression at mRNA level (P < 0.0001). C, Tn antigen targets H‐Ras to promote EMT in colorectal cancer. We proposed the hypothesis that expression of Tn antigen increases H‐Ras expression, which contributes to the intensive activation of EMT and consequently potentiates the malignant properties in colorectal cancer