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. 2019 Feb 11;10:84. doi: 10.3389/fneur.2019.00084

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Copyright © 2019 Huhn, Engelhorn, Linker and Nagel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MR images in a 33-years-old man with early RRMS. Examples of substantial sodium accumulation in two macroscopic T2 lesions with two different signal intensity patterns at T1-weighted imaging: one lesion was hypointense (solid arrows) and one was isointense (dashed arrows) to normal-appearing white matter on T1-weighted image. Figure reproduced from (99) with permission of the Radiological Society of North America (RSNA).