Table 2.
Overview of selected MBT case reports and case series to date, including current study. Patient age, tumor stage, and PFS are reported as median values.
| Authors | Year | Country | Cases reviewed | Age | Stage | Surgery (# pts) | Adjuvant treatment (# pts) | Clinical outcomes (# pts)b |
|---|---|---|---|---|---|---|---|---|
| Austin & Norris | 1987 | United States | 16 | 60 | IA | TAH, BSO (11); TAH, USO (2); USO (2); UO (1) | RT (2), RT + chemotherapya (1), none (14) | NED (9), DOD (5), DWED (2); PFS n/a |
| Gezginç, et al. | 2011 | Turkey | 13 | 50 | IIIC | TAH, BSO, omentectomy, LND (13) | CT (10), none (3) | AWD (7), NED (5), DWED; PFS 21 mo |
| Han, et al. | 2014 | South Korea | 10 | 55.5 | IA/IC | TAH, BSO, omentectomy, LND, appendectomy (8); USO (2) | CT (5), PT (1), none (4) | NED (6), AWD (1), DOD (2), DWED (1); PFS 16 mo |
| Lang, et al. | 2017 | United States | 1 | 77 | IIC | BSO, omentectomy, LND (1)c | CT (1) | NED (1); PFS 12 mo |
| Current study | 2019 | United States | 10 | 64 | IIA/IIB | TAH, BSO, Omentectomy, LND (4); TAH, BSO, Omentectomy (3); BSO, Omentectomy, LND (2); TAH, BSO (1) | CT (6), CT-NACT (1), CD (1), none (2) | NED (5), AWD (2), DOD (2), LTF (1); PFS 23 mod |
Abbreviations – AWD: alive with disease; BSO: bilateral salpingo-oophorectomy; CD: carboplatin/docetaxel; CT: carboplatin/paclitaxel; DOD: died of disease; DWED: died without evidence of disease; LTF: lost to follow-up; LND: lymph node dissection; n/a: data not available for review; NACT: neoadjuvant chemotherapy; NED: no evidence of disease; PFS: progression-free survival; PT: cisplatin/paclitaxel; RT: radiation therapy; TAH: total abdominal hysterectomy; UO: unilateral oophorectomy; USO: unilateral salpingo-oophorectomy.
Specific chemotherapy regimen was not reported.
Overall survival (OS) statistics were not uniformly reported through studies listed and thus not represented here.
Patient underwent prior hysterectomy for benign indication.
PFS calculation excludes one patient lost to follow-up immediately after initial surgery.