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. 2019 Feb 11;10:146. doi: 10.3389/fmicb.2019.00146

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Copyright © 2019 Gatica, Jurkevitch and Cytryn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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β-lactamase homologs gene network of analyzed metagenomes. Circles and Roman numerals represent clusters defined using network analyzer in Cytoscape. (A) Network color-code based on environment: bovine rumen (light green); bovine feces (dark green); human feces (purple); aerobic (activated sludge) municipal wastewater treatment (red), anaerobic municipal waste and food digestion reactors (brown); non-agricultural soil (yellow); agricultural soil (orange); glaciers (white); fresh water (light blue); marine (dark blue). Anaerobic municipal waste samples were primarily associated with Cluster I, whereas anaerobic food digesters all grouped in Cluster II. (B) Network color-coded based on geographical origin: United States (blue); Israel (light blue); Northern Europe (purple), Central Europe (orange); China (red); Australia (yellow).