Table 2.
Multivariable linear regression of variables with a potential influence on mycobacterial antibody levels. Values obtained using a multivariable regression model including age, quadratic age, sex, HIV and TB status, with P values and 99% CI (n = 1956)
| Variable | n (%) | Ag85A IgG OD | PPD IgG OD | LAM IgG OD | CFP10 ESAT 6 IgG OD | Ag85A IgM OD | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Coeff (99% CI) | P value | Coeff (99% CI) | P value | Coeff (99% CI) | P value | Coeff (99% CI) | P value | Coeff (99% CI) | P value | ||
| Sex | |||||||||||
| Male | 978/1956 (50.0%) | Baseline | Baseline | Baseline | Baseline | Baseline | |||||
| Female | 978/1956 (50.0%) | −0.002 (−0.045, 0.041) | 0.9 | −0.002 (−0.042, 0.038) | 0.91 | −0.017 (−0.099, 0.064) | 0.58 | −0.025 (−0.083, 0.033) | 0.27 | −0.012 (−0.103, 0.079) | 0.73 |
| HCMV tertiles | |||||||||||
| HCMV low | 650/1956 (33.2%) | −0.037 (−0.090, 0.016) | 0.07 | −0.009 (−0.051, 0.033) | 0.57 | −0.061 (−0.151, 0.030) | 0.08 | −0.100 (−0.156, −0.044) | <0.001 | −0.104 (−0.205, −0.004) | 0.01 |
| HCMV medium | 650/1956 (33.2%) | Baseline | Baseline | Baseline | Baseline | Baseline | |||||
| HCMV high | 656/1956 (33.5%) | −0.067 (−0.122, −0.012) | <0.001 | −0.057 (−0.105, −0.009) | <0.001 | −0.107 (−0.194, −0.019) | <0.001 | −0.015 (−0.077, 0.047) | 0.54 | −0.058 (−0.152, 0.035) | 0.11 |
| HIV status | |||||||||||
| Negative | 1860/1956 (95.1%) | Baseline | Baseline | Baseline | Baseline | Baseline | |||||
| Positive | 96/1956 (4.9%) | −0.240 (−0.361, −0.119) | <0.001 | −0.310 (−0.422, −0.198) | <0.001 | −0.420 (−0.586, −0.253) | <0.001 | −0.266 (−0.409, −0.123) | <0.001 | −0.446 (−0.640, −0.251) | <0.001 |
| TB status | |||||||||||
| Negative | 1929/1956 (98.6%) | Baseline | Baseline | Baseline | Baseline | Baseline | |||||
| Positive | 27/1956 (1.4%) | −0.101 (−0.322, 0.121) | 0.24 | −0.035 (−0.217, 0.147) | 0.62 | 0.158 (−0.107, 0.424) | 0.13 | 0.175 (−0.241, 0.590) | 0.28 | −0.135 (−0.609, 0.340) | 0.46 |