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. 2019 Feb 8;15:1744806919826789. doi: 10.1177/1744806919826789

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Intraperitoneal injection of GSK-3β inhibitor Styrene-butadiene copolymer (SB) 216763 prevents STM deficits in SNI rats but induces persistent mechanical allodynia and thermal hyperalgesia in sham rats. (a) The experiment designs are shown. (b) and (c) The time courses of the changes in PWT and PWL in different groups as indicated are shown. Note that injection of SB216763 (Styrene-butadiene copolymer [SB], 5 mg/kg, i.p.) did not affect the decrease in PWT and PWL induced by SNI but induced mechanical allodynia and thermal hyperalgesia in sham rats. n = 5-6 in each group, ***p < 0.001, compared with Vehicle (Vehi) + Sham group (repeated measures two-way ANOVA). (d) In the same cohort of rats, SB216763 prevented the decrease in recognition index of short-term memory induced by SNI but had no effect on sham rats. **p < 0.01, compared with Vehi + Sham group. ^#p < 0.05, ^###p < 0.001 vs. Vehi + SNI group (t-test). SNI: spared nerve injury; PWT: paw withdrawal threshold; PWL: paw withdrawal latency; NORT: novel object recognition test.