Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 8;15:1744806919826789. doi: 10.1177/1744806919826789

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 3. — Intrathecal injection of GSK-3β inhibitor analytical reagent (AR)-A014418 prevents STM deficits in SNI rats but induces persistent mechanical allodynia and thermal hyperalgesia in sham rats. (a) The experiment designs are shown. (b) and (c) The injection of AR-A014418 (400 ng/kg, 20 μl) did not affect the decrease in PWT and PWL induced by SNI but induced mechanical allodynia and thermal hyperalgesia in sham rats. n = 5–6 in each group, ***p < 0.001, compared with Vehi + Sham group (repeated measures two-way ANOVA). (d) In the same cohort of rats, AR-A014418 prevented the decrease in recognition index of STM induced by SNI but had no effect on sham rats. **p < 0.01 compared with Vehi + Sham group, ^###p < 0.001 vs. Vehi + SNI (t-test). (e) Representative photographs showing the Evans blue distribution (blue) in cerebrospinal fluid around spinal cord and brain (whole view, upper left), the ventral brain (bottom view, right), hippocampus, and the third ventricle (coronal view, left below) at 5 h after intrathecal injection (1%, 30 μl). SNI: spared nerve injury; BDNF: brain-derived neurotrophic factor; OD: optical density.