Figure 1.

Characterization of TNBS-induced colitis in WT and TLR4-deficient mice. (a) Photomicrographs of colonic sections from WT-TNBS, TLR4^−/−-TNBS, TLR4^−/−, and WT littermate controls as indicated. Scale bar = 100 μm. (b) DAI score for four subgroups during two-week period post TNBS or vehicle treatment (n = 5 per group, *p < 0.05; **p < 0.01; ***p < 0.001; two-way ANOVA followed by Bonferroni post hoc test). (c) Index of inflammatory infiltration for four subgroups. (d) Index of crypt epithelial damage for four subgroups (n = 5 per group, *p < 0.05; **p < 0.01; ***p < 0.001; one-way ANOVA followed by post hoc test). WT: wild type; TLR4: Toll-like receptor 4; KO: knockout; TNBS: 2,4,6-trinitrobenzene sulfate.