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. 2019 Feb 13;15:1744806919828921. doi: 10.1177/1744806919828921

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — PMA dose-dependent effects on ppNOC and NOP mRNA expression. Whole blood was cultured with different concentrations of PMA (0.1–300 ng/ml) or without PMA (control) for 24 h (ppNOC) or 6 h (NOP). PMA dose-dependently upregulated ppNOC (pEC₅₀: 0.45 (0.01–0.92)) and downregulated NOP mRNA (pIC₅₀: 0.61 (0.30–0.92)). Medians and interquartile ranges, n=4.

NOP: nociceptin opioid peptide receptor; ppNOC: prepronociceptin.