Figure 3.

Portimines induce apoptosis and reduce OCSCC proliferation. (A) ATP-based proliferation assays after 48 h exposure to 1 (left) and 2 (right); error bars indicate SD. (B) Taqman RT-qPCR analysis of cDNA libraries generated from OCSCC cell lines treated with the IC₅₀ (determined in A) for each compound; error bars represent SEM from three identical experiments performed in triplicate. (C) Electrophoretic resolution of genomic DNA harvested from HN12 cells exposed to 1 (left) or 2 (right) for 48 h.