Scheme 2. Synthetic Route B to Novel RXR Agonists.
Ragents and conditions: (a) EDC·HCl, 4-DMAP, CHCl3, reflux, 63%; (b) oxone, DMF, rt, 29%; (c) NaBH(OAc)3, DCE, HOAc, rt, 91%; (d) glacial acetic acid, formaldehyde, reflux, 54%.
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