Table 1.

Genetic variants linked to IPF by GWAS and Next-Generation Sequencing Studies

			Common Variants				Rare variants
Locus	Gene		SNP	OR	Progression/Survival		FIP	IPF		Reference
3q26	TERC		rs6793295	1.3			1–2%	0.80%		44, 51,52, 71
4q22	FAM13A		rs2609255	1.29	Protective					44
4q32	NAF1						~1%			60a
5p15	TERT		rs2736100	0.73			7–15%	4–5%		44, 51, 52, 70, 71
6q24	DSP		rs2076295	1.43						44
7q22	Intergenic		rs47274443	1.3						44
8p21	SFTPC						1–2%			61–63
10q22	SFTPA2						<1%			64
10q24	OBFC1		rs11191865	0.8						44
11p15	MUC5B		rs35705950	4.51	Protective					44–49
	MUC2		rs7934606	1.61						44
	TOLLIP		rs111521887	1.48						46
	TOLLIP		rs5743894	1.49						46
	TOLLIP		rs2743890	0.61	Protective					46
13q34	ATP11A		rs1278769	0.79						44
14q12	TINF2						<1%			59
14q21	MDGA2		rs7144383	1.44						46
15q14–15	Intergenic		rs2034650	0.77						44
15q25	AKAP13		rs62025270	1.27						45
16p13	ABCA3						<1%			65, 66
16p13	PARN						2–5%	1.2% – 2.7%		55, 60, 70, 71
17q21	MAPT		rs1981997	0.71						44
17q21	SPPL2C		rs17690703	0.7						46
19q13	DPP9		rs12610495	1.29						44
20q13	RTEL1						3–7%	2.3–3%		53, 54, 55, 70, 71
Xq28	DKC1						<1%			57

OR = odds ratio; FIP = familial interstitial pneumonia