Table 1.
Changes of macro- and microcirculatory parameters at baseline, 6 h, 30 h and 54 h. Values are presented as mean ± SD
| Group | Sham | CLP | CLP + LDK378 |
|---|---|---|---|
| MAP (mmHg) | |||
| BL | 124 ± 5.70 | 124.8 ± 6.91 | 123.2 ± 4.38 |
| 6 h | 120 ± 6.78 | 99.6 ± 9.24* | 98 ± 4.74* |
| 30 h | 113.4 ± 11.72 | 69.6 ± 12.93* | 86.4 ± 5.68*# |
| 54 h | 115.2 ± 6.38 | 46 ± 13.08* | 74.4 ± 7.06*# |
| PVD (mm/mm2) | |||
| BL | 18.91 ± 0.756 | 18.24 ± 0.62 | 18.63 ± 0.51 |
| 6 h | 18.9 ± 0.56 | 16.44 ± 2.61* | 16.87 ± 1.14 |
| 30 h | 18.45 ± 0.45 | 13.56 ± 2.19* | 16.14 ± 1.33*# |
| 54 h | 18.63 ± 0.86 | 12.45 ± 2.41* | 15.49 ± 1.01*# |
| MFI | |||
| BL | 2.9 ± 0.14 | 2.9 ± 0.14 | 2.95 ± 0.11 |
| 6 h | 2.85 ± 0.14 | 2.55 ± 0.27 | 2.6 ± 0.45 |
| 30 h | 2.7 ± 0.11 | 1.85 ± 0.22* | 2.3 ± 0.33*# |
| 54 h | 2.55 ± 0.21 | 1.5 ± 0.18* | 2.05 ± 0.33*# |
BL indicates baseline, MAP mean arterial pressure, MFI microcirculatory flow index, PVD perfused vessel density. *p < 0.05 compared with Sham group; #p < 0.05 compared with CLP group