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. 2019 Feb 18;7:24. doi: 10.1186/s40168-019-0632-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Enrichment of ARGs coding for different drug classes and resistance mechanism during the antibiotic exposure. Changes in the relative abundance of resistance mechanism (a) and drug classes (b) associated with ARGs detected before, during, and after antibiotic exposure. Day 0 (pre-exposure); days 1, 4, and 7 (exposure/florfenicol); and days 11, 13, 18, 26, and 34 (post-exposure). A control sample was taken on day 34 from a tank that did not receive the antibiotic during the whole experiment