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. 2019 Feb 18;17:13. doi: 10.1186/s12915-018-0623-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Crystal structures of the period proteins. a dPER (PDB 1WA9) and b mPER2 (PDB 3GDI) dimers in cartoon representation. The conserved Trp482 (dPER, dark blue) and Trp419 (mPER2, cyan) residues are shown in stick representation. c The domain architecture of dPER and mPER2 proteins. The two PAS domains (PAS-A and PAS-B), the cytoplasmic localization domain (CLD, green), the conserved C-domain (light brown), nuclear localization signals (NLS, purple), NES (red), the threonine-glycine (TG) repeat region, and the dCLK:CYC inhibition domain (CCID, blue) of dPER and/or mPER2 are shown. CKIe, mCRY1/2, and dTIM are shown at their binding sites. d dPER structure representing the PAS-A–αF interaction (encircled region) interface and depicting the location of V243 (blue)