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. 2019 Jan 31;10(2):180–185. doi: 10.1021/acsmedchemlett.8b00474

Figure 1.

Figure 1

Crystal structure of TET2-DNA complex.26 (a) TET2 binds dsDNA, breaks the double helix, and inserts 5mC into its active site. (b) View of the TET2 active site binding 5mC by forming hydrogen bonds with Asn1387, His1904, and Arg1261, all of which are critical residues for TET2 catalytic activity and methylated DNA binding. The oxidative iron center is shown in proximity to the methyl group on 5mC. (c) A 2D rendering of the 5mC-bound TET2 active site and critical residue interactions; blue = basic residue, red = acidic residue, and black = neutral residue.