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Examining possible methyl bioisosteres at the R1 position. Chloro, bromo, and trifluoromethyl-substituted derivatives were tested for inhibition of TET1- or TET2-mediated oxidation of methylated dsDNA. Each compound was tested at 100 μM in an ELISA. All data presented are N = 3, error bars indicate ± SEM. Two-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001.
