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. 2018 Oct 2;100(2):514–522. doi: 10.1093/biolre/ioy207

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© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

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Figure 4. — Specific role of ERα or ERβ in mediating E₂β stimulation of mRNA and protein expressions of CBS and CTH. (A, B) ERα or ERβ activation: primary uterine artery endothelial cells (UAECs) were treated with vehicle, 10 nM of estradiol-17β (E₂β), PPT (ERα agonist), DPN (ERβ agonist), or PPT + DPN for 48 h. (C, D) ERα or ERβ inhibition: primary uterine artery endothelial cells (UAECs) were treated with vehicle or estradiol-17β (E₂β) (10 nM) with or without 1 μM MPP (ERα antagonist), PHTPP (ERβ antagonist), or MPP + PHTPP. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CTH) mRNA (A, C) and protein (B, D) were determined. Data (means ± SEM) were collected from different cell preparations from three to five ewes. Bars with different letters differ significantly; capital and lower case letters pertain to CBS and CTH, respectively. *** P < 0.001 vs Control.