Table 1.
Differences between PsA and RA.
| Features | Psoriatic arthritis | Rheumatoid arthritis |
|---|---|---|
| Clinical | Asymmetrical arthritis lower limbs DIP joints, enthesitis, dactylitis, Axial arthritis |
Symmetrical MCP and wrist joints |
| Genetics | HLA-B38, -B39, and HLA-B27 HLA-cw6 IL-23/IL-17 pathway-related genes |
HLA-DRB1 PTPN22 |
| Pathogenesis | ||
| Autoantibodies | No | ACPA and RF |
| Synovial immunopathology | Innate immune cells (IL-17A+ Mast cells, Neutrophils) |
Adaptive immune cells (B and T-cells) |
| Synovial neoangiogenesis | Intense | Moderate |
| Vessels morphology* | Bushy, tortuous vessels | Straight, branching vessels |
| Radiology | Bone erosion and neoformation | Erosion |
| Therapeutic targets | TNFi Anti-IL-23/IL-12 Anti-IL-17A Anti-IL-23 |
TNFi Anti-B cells (anti-CD20) Anti-T cells (CTL4-Ig) Anti-IL-6 |
MCP, Metacarpophalangeal; DIP, distal interphalangeal; ACPA, Anti-Citrullinated Peptide Antibody; RF, Rheumatoid Factor; IL, Interleukin; TNFi, Tumor Necrosis Factor inhibitors;
*
Macroscopy vessels morphology as seen by arthroscopy.