Table 1.
Demographical and clinical variables among MDD patients and HCs.
| Blinded phase |
Active arm (N = 16) |
Sham arm (N = 16) |
t/χ2 | p | ||
|---|---|---|---|---|---|---|
| Mean | S.D. | Mean | S.D. | |||
| Age | 46.88 | 10.78 | 44.13 | 11.11 | 0.71 | 0.48 |
| Gender (female) | 11 (69%) | – | 10 (63%) | – | 0.14 | 0.71 |
| Medicated (%) | 16 (100) | – | 14 (87.5) | – | 2.13 | 0.14 |
| SES | 2.63 | 0.88 | 2.38 | 0.72 | 0.88 | 0.39 |
| ATHF-life | 5.06 | 3.17 | 5.56 | 2.13 | 0.52 | 0.60 |
| ATHF-current | 2.56 | 1.75 | 2.94 | 1.77 | 0.60 | 0.55 |
| MADRS-baseline | 25.44 | 5.73 | 21.94 | 3.13 | 2.14 | 0.04 |
| GAF-baseline | 52.63 | 4.67 | 55.56 | 4.27 | 1.86 | 0.07 |
| Response rate | 7 (44%) | 5 (31%) | 0.53 | 0.46 | ||
| Remission rate | 4 (25%) | 5 (31%) | 0.15 | 0.69 | ||
| Blinded + open-label phase |
MDD (N = 27) |
HCs (N = 20) |
t/χ2 | p | ||
|---|---|---|---|---|---|---|
| Mean | S.D. | Mean | S.D. | |||
| Age | 45.30 | 11.44 | 33.40 | 13.29 | 3.29 | 0.002 |
| Gender | 19 (70%) | – | 11 (55%) | – | 1.18 | 0.28 |
| Medicated (%) | 25 (92.6) | – | ||||
| Response | 13 (48%) | |||||
| Remission | 9 (33%) | |||||
Abbreviations: MDD, major depressive disorder; HCs, healthy control; SES: Socio-Economic Status; ATHF: Antidepressant Treatment History Form, total number of medication trials and augmentation strategies; MADRS: Montgomery-Asberg Depression Rating Scale; GAF: Global Assessment of Function.