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. 2019 Feb 16;5(2):e01231. doi: 10.1016/j.heliyon.2019.e01231

Fig. 6.

Fig. 6

Correlation between the R58/LAP-DP expression and histological findings of the liver in patients with NAFLD or viral hepatitis. (A) R58/LAP-DP deposition is observed at the edge of the biopsy specimens (arrows, left panel), resulting from tissue crushing during a needle biopsy or non-specific staining by R58 antibody. To eliminate this effect, the area less than 100 μm from the edge (shaded with pale red) was excluded from measurement (right panel). (B) The relationship between the R58/LAP-DP expression and the scores for steatosis, lobular inflammation, hepatocellular ballooning, NAS, or fibrosis in patients with NAFLD. (C) The relationship between the R58/LAP-DP expression and the degree of inflammation or fibrosis in patients with viral hepatitis. (D) A comparison of the R58/LAP-DP expression between patients with NAFLD and those with viral hepatitis. The extent of the R58/LAP-DP expression is represented as “% R58 (+) Area” in panels (B–D). The results shown represent the mean ± SD. Each dot represents the value for one patient. The Mann-Whitney U test and Kruskal-Wallis test were used for the statistical analyses. *P < 0.05, **P < 0.01.