Table 2.
NAFLD |
Viral hepatitis |
||
---|---|---|---|
Grade/Stage | (n) | Grade/Stage | (n) |
Steatosis (%steatotic hepatocytes) | |||
0 (<5%) | 0 | ||
1 (5–33%) | 19 | ||
2 (>33–66%) | 16 | ||
3 (>66%) | 11 | ||
Inflammation (foci/200x field) | Inflammation | ||
0 (no foci) | 2 | A0 (no activity) | 3 |
1 (<2 foci) | 21 | A1 (mild activity) | 25 |
2 (2–4 foci) | 17 | A2 (moderate activity) | 13 |
3 (>4 foci) | 6 | A3 (severe activity) | 2 |
Ballooning | |||
0 (none) | 11 | ||
1 (few ballooned cells) | 17 | ||
2 (many cells/prominent ballooning) | 18 | ||
NAS | |||
0–2 (simple steatosis) | 4 | ||
3–4 (borderline NASH) | 17 | ||
5–8 (definitive NASH) | 25 | ||
Fibrosis | Fibrosis | ||
0 (no fibrosis) | 3 | F0 (no fibrosis) | 3 |
1a (mild perisinusoidal) | 11 | ||
1b (moderate perisinusoidal) | 7 | F1 (portal fibrosis w/o septa) | 18 |
1c (portal/periportal) | 0 | ||
2 (perisinusoidal and portal/periportal) | 5 | F2 (portal fibrosis with few septa) | 17 |
3 (bridging fibrosis) | 20 | F3 (numerous septa w/o cirrhosis) | 4 |
4 (cirrhosis) | 0 | F4 (cirrhosis) | 1 |
NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH, non-alcoholic steatohepatitis; w/o, without. Histological grading and staging of NAFLD and chronic viral hepatitis were performed according to the NASH Clinical Research Network criteria and the METAVIR scoring system [12, 13, 14].