Table 3.
Overview of pathology per genotype.
| Organ | Gross pathology B.6/B.11 | Histopathology B.6/B.11 | Gross pathology B.12/B.20 | Histopathology B.12/B.20 |
|---|---|---|---|---|
| Lung | 10/10 with lesions: - 6/10 (multi-)focal hemorrhage(s) - 7/10 hyperemia - 6/10 edema - 3/10 emphysema - 2/10 foci (in one case described as yellow, dull, 2x3mm to 9x6mm foci) |
10/10 with lesions: - 6/10 with pneumonia: *5/6 necrotizing (n = 4) or necrotizing suppurative (n = 1) pneumonia, (sub-)acute, generally severe (n = 4) ± bacteria (n = 3), hemorrhages, hyperemia, edema, emphysema *1/6 suppurative interstitial pneumonia, acute, mild ± bacteria, hyperemia, edema, emphysema - 3/10 hemorrhage ± edema, hyperemia, emphysema - 1/10 only hyperemia, edema, emphysema |
5/15 NS - 10/15 with lesions: - 7/10 (multi-)focal hemorrhage(s) - 4/10 hyperemia - 7/10 edema - 1/10 emphysema - 1/10 foci (described as one firm white nodule) |
15/15 with lesions: - 2/15 with pneumonia: 15 necrotizing pneumonia *1/15 necrotizing pneumonia, sub-acute, severe with hemorrhages, and hyperemia *1/15 acute mild suppurative interstitial pneumonia with hyperemia, edema - 5/15 hemorrhage ± hyperemia, edema, emphysema - 8/15 only hyperemia, edema, emphysema |
| Trachea | 1/10 NA - 1/9 NS - 8/9 with lesions: - 6/8 hyperemia - 2/8 hemorrhage |
8/10 NA - 2/10 with lesions: - 1/2 hemorrhage in serosa - 2/2 hyperemia |
5/15 NS 10/15 with lesions: - 7/10 hyperemia - 5/10 hemorrhage - 1/10 edema |
15/15 NA |
| Heart | 10/10 NS | 9/10 NS - 1/10 with lesions: - 1/1 subendocardial petechia |
1/15 ND 12/14 NS 2/14 with lesions: - 1/2 beige-pink color - 1/2 yellow aorta (icterus) |
1/15 NA 13/14 NS 1/14 with lesions: - 1/1 aorta hemorrhage |
| Spleen | 10/10 with lesions: - 10/10 splenomegaly |
10/10 with lesions: - 9/10 splenitis: *8/9 necrotizing (n = 7) or necrotizing suppurative (n = 1) splenitis, acute, generally severe (n = 6), ±bacteria (n = 3), hemorrhages in the red pulp (n = 4) *1/9 necrotizing granulomatous splenitis, subacute, severe, with lymphodepletion - 1/10 hyperemia and PALS |
5/15 NS - 10/15 with lesions: 10/10 splenomegaly |
2/15 NA (autolytic) 13/13 with lesions: - 9/13 necrotizing splenitis, acute, generally severe (n = 8), ±bacteria (n = 3), hemorrhages in the red pulpa (n = 1), and lymphodepletion (n = 4). - 1/13 acute hemorrhages - 3/13 only hyperemia ±hyperplasia white pulp (n = 1), PALS (n = 2) |
| Lymph nodes | 10/10 NS | 7/10 NA 3/10 with lesions: - 3/3 necrotizing lymphadenitis, cervical (n = 1), bronchial (n = 1), mesenterial (n = 1), with bacteria (n = 2) |
14/15 NS - 1/15 with lesions: - 1/1 enlarged mesenteric lymph nodes |
13/15 NA 2/15 with lesions: - 2/2 necrotizing lymphadenitis, bronchial (n = 1) and mesenterial (n = 2) ln, ± bacteria (n = 1), hemorrhages (n = 1) |
| Liver | 3/10 NS - 7/10 with lesions: - 5/7 reduced consistency - 3/7 enlargement - 2/7 beige color - 1/7 hyperemia - 1/7 dull (necrosis) - 1/7 foci, widespread light-yellow foci |
10/10 with lesions: - 10/10 necrotizing hepatitis, focal (n = 1) or multifocal (n = 9), (sub)acute, mild (n = 3) to severe (n = 7) |
1/15 ND 3/14 NS 11/14 with lesions: - 3/11 reduced consistency - 3/11 enlargement - 3/11 multifocally beige - 1/11 hyperemia - 1/11 dull (necrosis) - 1/11 foci, multifocal, white, 1-2 mm diameter |
15/15 with lesions: - 14/15 necrotizing hepatitis, focal (n = 1) or multifocal (n = 12), (sub)acute, mild (n = 1) or severe (n = 13), ±bacteria (n = 2) - 1/15 hyperemia |
| Stomach | 9/10 NS 1/10 empty | 4/10 NA (autolytic) 6/10 NS | 14/15 NS 1/15 empty | 2/15 NA (autolytic) 13/15 NS |
| Intestine | 5/10 NS 5/10 with lesions or abnormal contents: - 1/5 hyperemic duodenum with red fluid (blood) in lumen - 1/5 thickened colon wall with red (blood) mucus in lumen - 3/5 beige-brown (mucous) fluid in lumen |
2/10 NA (autolytic) 6/8 NS (nematodes n = 4) 2/8 with lesions: - 2/2 hemorrhages in colon, serosa (n = 1) or mucosa (n = 1) |
1/15 ND 10/14 NS 4/14 with lesions or abnormal contents: - 1/4 with hyperemic duodenum. - 3/4 remaining cases: brown (mucous) fluid in lumen |
3/15 NA (autolytic) 10/12 NS (nematodes n = 4; coccidia n = 3) 2/12 with lesions: - 1/2 necrosis submucosa colon - 2/2 hemorrhages in colon, serosa (n = 1) or mucosa (n = 1) |
| Adrenals | 10/10 NS | 1/10 NA 3/9 NS 6/9 with lesions: - 4/6 necrotizing adrenalitis, focal (n = 1) to multifocal (n = 3), mild (n = 1) to severe (n = 3), subacute (n = 1) to acute (n = 3) ±bacteria (n = 4) - 2/6 hyperemia with bacteria |
3/15 ND 12/12 NS | 3/15 NA 3/12 NS 9/12 with lesions: - 3/9 necrotizing adrenalitis, focal (n = 2) to multifocal (n = 1), mild (n = 2) to severe (n = 1), acute (n = 3) ±bacteria (n = 1) - 2/9 capsule hemorrhage - 3/9 hyperemia - 3/9 bacteria, no reaction |
| Kidney | 6/10 NS 4/10 with lesions: - 2/4 hyperemia - 1/4 diffusely beige - 1/4 multifocal beige areas (amyloid) |
5/10 NS - 5/10 with lesions: - 4/5 hyperemia - 1/5 amyloidosis (incidental finding) |
1/15 ND 10/14 NS 4/14 with lesions: - 1/4 hyperemia - 2/4 diffusely beige - 1/4 reduced consistency - 1/4 yellow papil (icterus) |
2/15 NA 10/13 NS 3/13 with lesions: - 3/3 hyperemia |
| Serosa with fat tissue | 9/10 NS 1/10 with lesions: - 1/1 multiple 1mm diameter foci in spleen serosa, uterus serosa, mesometrium and abdominal diaphragm. |
6/10 NA 4/10 with lesions: 4/4 hemorrhage in serosa/fat surrounding thyroid (n = 1), pancreas (n = 1), kidney (n = 1) gonad (n = 1) | 14/15 NS 1/15 with lesions - 1/1 with 1 yellowish focus in mediastinum |
10/15 NA - 5/15 with lesions: - 2/5 necrotic foci in fat tissue, e.g. around gonad with bacteria - 3/5 hemorrhage in fat/serosa next to cervical ln, thyroid, or pancreas |
| Integument, musculo-skeletal system | 5/10 NS 5/10 with lesions (trauma): - 1/5 fracture - 5/5 hemorrhages in neck (n = 1; killed), head (n = 2), intra-thoracic (n = 1), intra-abdominal (n = 1) |
9/10 NA 1/10 with lesion - 1/1 epithelial ulceration eyelid with hemorrhage and bacteria (trauma) |
8/15 NS 7/15 with lesions (trauma): - 1/7 fracture - 2/7 ruptured skin - 4/7 hemorrhages in neck (n = 2), head (n = 1; killed), intra-abdominal (n = 1) |
15/15 NA |
| Eye | 10/10 NS (n = 1 missing#) | 10/10 NA | 14/15 NS (n = 1 missing#) | 15/15 NA |
| Brain | 9/10 NS 1/10 with lesions: - 1/1 intracranial hemorrhage and around cervical spinal cord (trauma) |
10/10 with lesions: - 1/10 severe necrotizing meningoencephalitis cerebrum with perivasculitis and hemorrhages - 2/10 hemorrhage in meninges (n = 1) or cerebellum (n = 1) - 10/10 hyperemia meninges (n = 4), cerebellum (n = 3), around hypophysis (n = 2), choroid plexus (n = 1). |
4/15 ND 9/11 NS 2/11 with lesions: - 1/2 hemorrhage (trauma; killed) - 1/2 hyperemia |
1/15 NA 4/14 NS 10/14 with lesions: - 7/10 hemorrhages e.g., in cerebrum (n = 2), cerebellum (n = 2), medulla oblongata (n = 1) - 9/10 hyperemia, e.g., in meninges (n = 2), cerebrum (n = 4) cerebellum (n = 1), medulla oblongata (n = 1) |
NS, no significant lesions; ND, not determined; NA, Not available.
PALS, peri-arterial lymphocytic sheets.
#scavenged.