Vitamin or mineral	Daily exposure estimate from food sources, excluding supplements, for men and women in the UK (mg) (Gregory 1990)		Reference Nutrient Intake (RNI) for adults (= the amount of a nutrient that is enough to ensure that the needs of nearly all a group (97.5%) are being met) set by UK Committee on Medical Aspects of Food and Nutrition Policy (COMA) in 1991 (Food Standards Agency 2003)	Supplementary doses used in studies included in this review (mg)
	Mean	95%ile
Folic acid	0.26	0.49	0.20	0.4 ‐ 5.0
Vitamin B6	2.0	3.9	1.4 (men), 1.2 (women)	20 ‐ 50
Vitamin B12	0.0062	0.020	0.0015	0.4 ‐ 1.0
Vitamin C	64	160	40	400
Vitamin E	8.5 (12.69 IU)	18 (26.87 IU)	Requirement varies widely with diet, no fixed level of intake recommended. COMA concluded that daily intakes of 4mg and 3mg of α‐tocopherol equivalents (5.97 IU and 4.48 IU) could be adequate for men and women respectively (Food Standards Agency 2003)	330 ‐ 2000 IU (International Units)
Chromium	0.1 (source MAFF 1999)	0.17	COMA has set no RNI but suggests intake above 0.025mg/day is adequate for adults.US National Research Council specify an Estmated Safe and Adequate Daily Dietary Intake (ESADDI) of 0.05‐2.0mg/day for adults.	1.0