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. 2018 Nov 1;2018(11):CD011905. doi: 10.1002/14651858.CD011905.pub2

ACTRN12607000321448.

Methods Randomised placebo controlled trial.
Participants Location: Australia. Single centre.
Setting of recruitment and treatment: WA Centre for Health & Ageing, University of Western Australia.
Inclusion criteria:
  • Adults with mild cognitive impairment (‐1.5 standard deviations below norm on any task in the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) neuropsychological battery);

  • Over 65 years of age;

  • Vitamin D concentration between 12.5 and 50 nmol/L at baseline.


Exclusion criteria:
  • · Diagnosis of osteoporosis requiring treatment;

  • · No informant available;

  • · Severe physical or medical illness that would preclude completion of the trial;

  • · Hearing or visual impairment that would preclude assessments;

  • Already in an intervention trial;

  • · Clinical history of stroke;

  • · Fall in the last 3 months;

  • · Heart attack in the last 3 months;

  • · Fall with fracture over the age of 65 years;

  • · History of kidney or bladder stones;

  • · Current acute depression;

  • · History of schizophrenia;

  • · Current diagnosis of dementia.

Interventions Intervention :
1000 IU vitamin D daily by oral tablet.
Comparator group:
Placebo (soyabean oil tablet indistinguishable from active tablet).
Outcomes Outcomes of interest in the review:
Overall cognitive functioning: Cambridge Examination for Mental Disorders in the Elderly ‐ Cognitive section (CAMCOG);
Specific cognitive functioning subdomain: executive function: digit‐symbol coding task;
Specific cognitive functioning subdomain: episodic memory: California Verbal Learning Scale‐Revised;
Development of dementia;
Quality of life: SF‐12.
Reason awaiting classification Only publication of baseline results and protocol found. No results available after contact with authors.
Notes National Health and Medical Research Council Dementia Research Grants Program